Danazol treatment for paroxysmal nocturnal hemoglobinuria.
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منابع مشابه
Danazol treatment for paroxysmal nocturnal hemoglobinuria.
Danazol was administered to two patients with paroxysmal nocturnal hemoglobinuria (PNH) with a dramatic effect on the hematological findings. The patients, 31- and 41-year-old females, were initially diagnosed as having aplastic anemia, and were initially treated with anabolic steroid and immunosuppressive therapy, respectively. Sugar water and Ham tests turned positive at the start of danazol ...
متن کاملTreatment of paroxysmal nocturnal hemoglobinuria.
Patients with PNH may be treated with a number of known agents. As in all patients with a chronic disease, a regimen tolerable over a long period of time must be selected. Knowledge and anticipation of complications and their proper treatment are essential parts in the treatment. When these principals are used, many patients may live reasonable lives for very long periods of time.
متن کاملParoxysmal nocturnal hemoglobinuria.
Paroxysmal Nocturnal Hemoglobinuria (PNH) literally means to have episodes of hemoglobin in the urine during the night. It is a Coomb's negative rare hemolytic disorder characterized by non-malignant clonal expansion of haemopoietic stem cells due to acquired genetic mutations. A 30 years old male patient presented with 5 years history of transfusion dependent anemia with intermittent episodes ...
متن کاملTreatment of paroxysmal nocturnal hemoglobinuria with ACTH.
pAROXYSMAL NOCTURNAL HEMOGLOBINURIA is a rare hemolytic disease characterized by intravascular hemolysis and excretion of hemoglobin in the urine during sleep. Crosby,’ in an extensive review of the literature, found reports of 123 cases of this condition and gave credit to StrUbing for first recognizing it as an entity in 1882. It was not until another description was published by Marchiafava2...
متن کاملParoxysmal nocturnal hemoglobinuria.
Keywords Disease name and synonym Definition and Differential Diagnosis Etiology Clinical Description Diagnostic Methods Epidemiology Management References Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the bone marrow characterized by the lack (total or partial) of all proteins normally attached to the cell membrane by the glycosylphosphatidylinositol (GPI...
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ژورنال
عنوان ژورنال: Japanese Journal of Medicine
سال: 1990
ISSN: 0021-5120,1881-123X
DOI: 10.2169/internalmedicine1962.29.417